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External Access > PubMed LinkOut
ISSN Number: 1203-4754
Title: Journal of Cutaneous Medicine and Surgery
Volume Number: 17
Issue Number: 02
Page Number: 114
Published: 6 time(s) per Year

Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without A Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne

Background:Systemic antibiotics are an effective treatment for acne vulgaris. However, intolerable side effects may invariably occur.Objective:To determine whether probiotics reduce the side effects imparted by systemic antibiotics while working synergistically with the latter in treating inflammatory acne.Methods:Forty-five 18- to 35-year-old females were randomly assigned to one of three arms in this prospective, open-label study. Group A received probiotic supplementation, whereas group B received only minocycline. Group C was treated with both probiotic and minocycline. Clinical and subjective assessments were completed at baseline and during the 2-, 4-, 8-, and 12-week follow-up visits.Results:All patients demonstrated a significant improvement in total lesion count 4 weeks after treatment initiation (p < .001), with continued improvement seen with each subsequent follow-up visit (p < .01). At the 8- and 12-week follow-up visits, group C had a significant decrease in total lesion count versus groups A (p < .001) and B (p < .01). Two patients (13%) from group B failed to complete the study secondary to vaginal candidiasis.Conclusion:Probiotics may be considered a therapeutic option or adjunct for acne vulgaris by providing a synergistic antiinflammatory effect with systemic antibiotics while also reducing potential adverse events secondary to chronic antibiotic use.
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