|
|
External Access > PubMed LinkOut
|
ISSN Number: 1916-0216
Title: Journal of Otolaryngology-Head And Neck Surgery
Volume Number: 41
Issue Number: 02
Page Number: 124
Published: 6 time(s) per Year
|
|
AbstractBackground:Early-stage laryngeal squamous cell carcinoma is managed with radiotherapy or endoscopic surgery. Although cure rates are high, radiation failures often require total laryngectomy for salvage. Biomarkers that can predict tumour radioresistance may be useful in modifying the treatment approach for individual patients.Methods:Retrospective patient chart review yielded 75 patients with T1–T2 glottic squamous cell carcinoma treated with radiation therapy at the London Health Sciences Centre. Pretreatment tumour biopsies were immunostained for B-cell lymphoma 2 (Bcl-2), Ki-67, and epidermal growth factor receptor (EGFR) to correlate biomarker expression with disease-free survival (DFS).Results:Ki-67 expression was strongly associated with recurrence following radiation and independently predicted poor DFS (hazard ratio 4.86, 95% CI 1.58–15.00; p = .006). EGFR and Bcl-2 were not associated with a risk of recurrence.Conclusions:Ki-67 expression identified a subset of patients with increased risk of local recurrence after radiation therapy. Ki-67 expression can potentially guide improved personalized treatments for patients with early-stage glottic squamous cell carcinomas.
If you are not a current online subscriber to Journal of Otolaryngology-Head And Neck Surgery then please click on the link below to purchase the article:
|
|
|
|
